MICR 2420 Lecture Notes - Lecture 12: Phagocyte, Innate Immune System, Antigenic Variation
28 Mar 2016
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Document Summary
Nonadaptive (innate) immunity: barriers to infection, nonspecific responses to destroy invading pathogens, present from birth. Adaptive immunity: reaction to specific antigens. Parts of foreign proteins, polysaccharides, other structures: retains memory to give faster subsequent response. Connection between the immune system and an effective pathogen. Transferred through air vs. bodily fluids: replication speed ex. Tuberculosis, it takes 24 hours for one cell to divide into two: level of destruction ex. Toxins: structures that can mimic host structures. Immune cells differentiate from stem cells in the bone marrow. Monocytes differentiate into macrophages and dendritic cells. Have the memory, get activated with vaccines. T cells: modulate specific immune response and kill abnormal infected host cells. B cells: produce antibodies to bind antigens, once they"ve been activated have a lot of rer. Innate immunity: physical barriers, molecules, calls and processes: phagocytes/phagocytosis, neutrophils are the primary phagocytes in blood, macrophages are the primary phagocytes in tissues.
