MICR 2420 Lecture Notes - Lecture 13: Phagocyte, Lysozyme, Protozoa
10 Apr 2016
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Document Summary
Acute inlammaion is useful at quickly addressing infecion. Chronic inlammaion: coninuously simulated inlammatory pathways, eventually causes major damage. Irritants (like splinters, surgical implants, inhaled paricles like asbestos (cause cancer in lungs) Example: mycobacterium tuberculosis hides inside macrophages, switches of pathway to prevent lysophagosome formaion (cell sill sends signals to trigger inlammaion), forms tubercles. Fever is part of inlammatory response, heightens acivity of innate immunity. Process the anigens they ingest and display them on their surface for t cells. Macrophages and dendriic cells are apc"s: phagocytosis of anigen, formaion of lysophagosome, enzymes degrade anigen, fragments presented on apc surface via mhc, letover fragments released by exocytosis. Lactoferrin: deprives pathogens of iron (important, good o2 carrier) Enzymes that make reacive oxygen species (superoxide ions, hydrogen peroxide, hydroxyl radicals, hydroxide ions) Macrophages and neutrophils also make reacive nitrogen species (nitric oxide, nitrate ions) Create an oxidaive burst, short enough that phagocyte is not afected, but concentrated enough that pathogen is fatally damaged.
