MICR 3230 Lecture Notes - Lecture 3: Tight Junction, T-Cell Receptor, Natural Killer Cell

• School: University of Guelph
• Department: Microbiology
• Course: MICR 3230
• Professor: Kaushik/ Mallard

Document Summary

Chemical (acidic ph eliminates many organisms, anti-microbobial proteins and. If bacteria enters the immune system, this is when the cellular response begins via nk cells, Dc"s (cid:894)phago(cid:272)(cid:455)tose a(cid:374)d degrade pathoge(cid:374)s, a(cid:374)d the(cid:374) prese(cid:374)t o(cid:374) surfa(cid:272)e a(cid:374)d (cid:373)o(cid:448)e to l(cid:455)(cid:373)ph cells to initiate adaptive immune responses) I(cid:374)(cid:374)ate (cid:894)hours is for the re(cid:272)ruited (cid:272)ells that are (cid:272)alled to the site of the i(cid:374)fe(cid:272)tio(cid:374) (cid:373)i(cid:374)utes if for resident cells already at the site of infection) (cid:373)u(cid:272)h less spe(cid:272)ifi(cid:272) (cid:272)a(cid:374) kill a(cid:374)d phago(cid:272)(cid:455)tose dead a(cid:374)d d(cid:455)i(cid:374)g (cid:272)ells in addition to pathogens. Highly diverse because of vcrs and tcrs (genetic recombination) Self-reactive b cells and t cells can avoid negative selection and cause problems (autoimmune disease) Epithelial barriers: connected by tight junctions (junctions that are connected so tightly it is impossible for anything to get through) Goblet cells that produce mucous that lines epithelial walls, so if foreign object/pathogen enters it becomes trapped, and then brushed out of the body by cilia.