MICR 3230 Lecture Notes - Lecture 8: Fragment Antigen-Binding, Immunoglobulin Domain, Master Of Veterinary Science

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One gene will encode for kappa, the other will encode for lambda. The two light-chain subtypes ( or , kappa or la(cid:373)(cid:271)da(cid:895) The five heavy-(cid:272)hai(cid:374) su(cid:271)(cid:272)lasses (cid:894) , (cid:2747), , (cid:2748), or ) Hinge region (between ch1 and ch2) (allows for the arms of the antibody to flex out and inward) The amino-terminal portions bind to antigen (the antigen binding portion) The carboxy-terminal domains mediate effector functions (fc portion) Each light chain is bound to its partner heavy chain by: The two heavy chains are bound together by: Paired vl/vh (variable region of light and heavy chains) and cl/ch1 domains. Fab = fragment antigen binding (this part of the molecule binds to antigen) All disulfide bonds break and you are left with 4 separate chains: two light and two heavy chains. Anti-parallel -pleated strands, arranged into a pair of sheets. The strands of each sheet (in different colors) Loosely folded regions link one strand to the next strand.

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