MICR 3330 Lecture Notes - Lecture 9: Vpr, Transfer Rna, Candidiasis
27 Jun 2018
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HIV and AIDS
A recent zoonotic disease that is most dreadful of modern civilization
World AIDs Day : December 1st
The Discovery
Pneumocytis pneumonia: Los Angelas
1980: men were treated for biopsy-confirmed Pneomocytis carinii
Identification by three groups: Pasteur Institute (Lymphadenopathy associated virus- LAV)
NIH (Human T cell lymphotropic virus- HTLV
UC-San Franciso (AIDS-associated retrovirus- ARV)
ICTV: Human immunodeficiency virus
Pasteur Institute was first to discover HIV
Virologists Receiving Nobel Prize-2008
NIH- Gallo
PI- Montagnier and Sinoussi
Global HIV Incidence
15-34% of population were infected: vast majority in Ssub-sahran Africa
Incidence and Mortalities
35 million living with AIDS: ~1% of population 15-49 years old
39 million in mortalities
In Sub-Saharan region: 1 0f 20 adults are infected
Death rate declining due to anti-viral therapy
The numbers are scary
1 person dies every 11 seconds of AIDS
1 person every 9 seconds is infected with AIDS
2006 most deaths
worldwide 33.5 million living with AIDS
HIV and AIDs have been on the decline
75% of people living with HIV/AIDS are located in 15 countries
Top 8 countries include: South Africa, Nigeria, india and kenya etc..
Was declined bc of implementation of blood screening in 1990
Taxonomy and Representatives: Genus
Simple retroviruses (encoding Gag, Pro, Pol and Env): Alpharetrovirus, Betaretrovirus,
Gammaretrovirus
Complex retroviruses (encoding Gag, Pro, Pol, Env and accessory proteins): Deltaretrovirus,
Epsilonretrovirus, Spumavirus and Lentivirus (HIV-1 and HIV-2)
find more resources at oneclass.com
find more resources at oneclass.com
Genome: +ssRNA
9.3 kb (2 copies of each virion, also described as “diploid”
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
A recent zoonotic disease that is most dreadful of modern civilization. 1980: men were treated for biopsy-confirmed pneomocytis carinii. Identification by three groups: pasteur institute (lymphadenopathy associated virus- lav) Nih (human t cell lymphotropic virus- htlv. Pasteur institute was first to discover hiv. 15-34% of population were infected: vast majority in ssub-sahran africa. 35 million living with aids: ~1% of population 15-49 years old. In sub-saharan region: 1 0f 20 adults are infected. Death rate declining due to anti-viral therapy. 1 person dies every 11 seconds of aids. 1 person every 9 seconds is infected with aids. Hiv and aids have been on the decline. 75% of people living with hiv/aids are located in 15 countries. Top 8 countries include: south africa, nigeria, india and kenya etc Was declined bc of implementation of blood screening in 1990. Simple retroviruses (encoding gag, pro, pol and env): alpharetrovirus, betaretrovirus, Complex retroviruses (encoding gag, pro, pol, env and accessory proteins): deltaretrovirus,
