Class Notes (811,485)
Canada (494,756)
Microbiology (210)
MICR 2420 (131)
Lecture 17

MICR 2420 Lecture 17: Lecture 17 Viruses

4 Pages
Unlock Document

MICR 2420
Lucy Mutharia

Lecture17:Viruses HIV: Human Immunodeficiency Virus AIDS: Acquired Immunodeficiency Syndrome Its genome is already messenger RNA and can be used right away for making proteins Is a lot more protein and a lot more complex (AIDS) Both have a virion and capsid The virion contains the genome and accessory protein The nucelocapsid protein is located inside There are 2 key proteins that are glutamate and gluraminidase The host is binded to the infection HIV is a Retrovirus Retroviruses are a major class of RNA viruses Reverse the normal order of synthesis to copy transcribe their RNA genome into dsDNA which is then integrated into the host chromosome HIV is in the Lentiviruses group of retroviruses Cause infections that progress slowly over many years (lenti = slow) Most famous is Acquired Immunodeficiency Syndrome (AIDS) It is transmitted through blood, genital or oralgenital contact, mother to child HIV Causes AIDS HIV evolved from viruses infecting African monkeys Two major types are recognized: HIV1 and HIV2 1981, first cases of HIV were reported in the USA Western society failed to grasp the significance of the virus Largely ignored because it affected was reported in marginalized minority groups Since the beginning of the epidemic, 78 million people have been infected with the virus, about 39M have died of HIV 2013: Globally 35M people were living with HIV In Canada, 1 in 5 people with HIV are unaware that they are infected Approximately 50,000 people in the United States are newly infected with HIV each year HIV Discovery French virologist Luc Montagnier and American virologist Robert Gallo published their discovery of the virus in the same issue of Science in 1983 Dispute about who discovered it first began Isolated viruses from each lab turned out to be almost identical Gallo was accused of fraud In the end it was found that this was not the case Contaminated samples were sent from Montagniers lab to Gallos lab 2008: Montagnier, not Gallo, won the Nobel prize for his discovery No cure* for AIDS (yet): why? The replication of HIV is very complex Large number of regulator proteins that allow the virus to hide effectively within host cells Retroviruses have a high mutation rate because of high error rate of the reverse transcriptase enzyme Even within a single patient, the virus evolves into many different quasispecies Envelope antigens constantly changing > allows immune escape
More Less

Related notes for MICR 2420

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.