MICR 2430 Lecture Notes - Lecture 5: Psychrophile, Mesophile, Membrane Fluidity
20 Mar 2017
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Abc transporters: atp-binding cassette transporters: found in all life forms, for import and export (including of drugs, multi-drug efflux, through conformational changes, examples to remember: maltose and histidine, 1. Solute binds to its cognate periplasmic binding protein, and the complex then binds to the membrane transporter: 2. The atpase activity of one component (yellow) signals the opening of the channel (blue) and movement of the solute into the cell. The phosphotransferase system one example of group translocation: 1. Phosphate from pep is passed along common elements of the pts to the modular enzyme 2, and ultimately to the substrate: enzyme 2 components are modular, 2. Substrates are transformed by phosphorylation during transport: mannitol enters, 3. Enzyme 2c transports substrate across the cell membrane. Enzyme 2b transfers phosphate to the sugar transported across the cell by 2c: glucose enters, only found in bacteria and archaea, only for very specific substrates, only for organisms that would use those substrates.
