MICR 3330 Lecture Notes - Lecture 2: Rolf M. Zinkernagel, Tradd, Memory T Cell
3 Feb 2018
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The arms race between a virus and its host: virus offense meets host defense. How the immune system distinguishes virus infected cells from healthy cells. Done by peter doherty and rolf zinkernagel. Looked at the response of mice to viruses and found that wbc must recognize both the virus and certain self-molecules (major histocompatibility antigens) in order to kill the virus infected cells. Abrasion of skin: arthropod sting, scratch, injury, rabid dog bite. Respiratory tract: air-borne pathogens (common cold, flu, chicken pox, adenoviruses, etc. ) Alimentary tract: oral-fecal route of transmission, food-borne, water-borne. B and c, hiv, hhv-2 [herpes simplex virus type 2], etc. ) Surgical procedures: organ transplantation, transfusion of blood and blood products. Interplay between viral offense and host defense determines outcome of an infection. Those that cause acute infections will need to reach out to infect a population. Those (cid:272)ausi(cid:374)g persiste(cid:374)t i(cid:374)fe(cid:272)tio(cid:374)s te(cid:374)d to (cid:271)e (cid:862)loyal(cid:863) a(cid:374)d stay (cid:449)ith the i(cid:374)fe(cid:272)ted host for a long period of time.
