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Lecture 3

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University of Guelph
MICR 4010
Rob Foster

BACTERIAL SECRETION - Gram-positives -> tend to use the General Secretory Pathway (GSP) - Gram-negatives -> proteins secreted have to get through the outer membrane (OM) Type 1 secretion systems (T1SS) - Independent of the GSP - Also known as ATP-binding cassette (or ABC) transporters - Also works for non-proteins - Protein moves through IM and OM without stopping Type 3 Secretion systems (T3SS, sometimes TTSS) - Independent of the GSP - Molecular syringe - Related to flagellar apparatus - For secretion of protein effectors directly into the host cell (as well as into the extracellular milieu) - Requires ATP - E.g. Salmonella, Bordetella, Pseudomonas, EPEC, EHEC Type 4 secretion systems (T4SS) - Independent of the GSP - Related to the conjugal pili system - Translocate protein or complexes of protein + ssDNA - Almost always require host-cell contact to initiate delivery - Requires ATP - H. pylori, Legionella pneumophila, Brucella spp., Coxiella burnetii, Bartonella spp. Type 2 secretion systems (T2SS) - GSP-dependent (requires ATP) - Transport across the OM facilitated by a complex secreton - May involve a piston-like structure in the IM to help push the secreted protein through - E.g. Klebsiella, V. cholerae, P. Aeruginosa Type 5 secretion systems (T5SS) - GSP-dependent (requires ATP) - ‘autotransporter’ secretion - Haemophilus influenzae, H. Pylori, Neisseria spp. Chaperone-usher pathway - GSP-dependent - Liked to assembly of adhesive structures on the bacterial surface Type 6 secretion systems (T6SS) - Independent of the GSP - ATP-dependent
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