MBG 2400 Lecture Notes - Lecture 1: Nuclear Receptor Coactivator 1, Ovulation, Birth Weight

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 2400
• Professor: Barry Micallef

Document Summary

Proportion of total variance that is additive genetic and is transmitted from parent to offspring. Typically, quantitative traits involve many loci: 10, 100, 1000. Most loci have a small effect: cant find/detect individual loci. Occasionally some loci have a larger effect if the effect is significant, we can find them. Goal: find a polymorphism in the genome that is associated with a distinct diff in phenotype. Concept is simple but execution can get complicated. Individual locus genotyping: m and m for marker loci, q and q for qtl. Most qtl are discovered using markers: usually a(cid:374) (cid:862)u(cid:374)i(cid:373)porta(cid:374)t(cid:863) poly(cid:373)orphis(cid:373, nor(cid:373)ally do(cid:374)"t ge(cid:374)otype the qtl itself. Have 81,652 qtls top 15 qtl traits; age at puberty, milk yield fat, milk yield, calving ease, body weight gain. Number of qtls on each chromosome; 1 = 700, 6 = 1556, x = 197: catfish 0 qtls, chicken 5683 qtls, pig qtl/associations data summary.