MBG 2400 Lecture Notes - Lecture 1: Missense Mutation, Nonsense Mutation, Silent Mutation
1 Oct 2017
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Tutorial assignment for mutation, dna repair and recombination. Chapter 13: lecture topics: sources of genetic variability, the molecular basis of mutation, dna repair mechanisms. The assignment questions are based upon information presented in lectures on these topics. To enhance understanding and develop analytical skills, students are also encouraged to peruse the basic exercises and problems at the end of chapter 13. Assignment questions to be answered in advance of the tutorial. A codon table is provided on the last page of this assignment. 1 a) list the purine bases: b) list the pyrimidine bases: c) distinguish between a transition and a transversion mutation: what is a tautomeric shift? e) tautomeric shifts usually result in transition mutations. The x-linked gene that encodes the enzyme glucose-6-phosphate dehydrogenase (g6pd) is 18 kilobase pairs in size, with 13 exons. The enzyme has a molecular mass of 58 kda and consists of 531 amino acids. A man has a null allele of the g6pd gene.
