MBG 3080 Lecture Notes - Lecture 6: Missense Mutation, Nonsense Mutation, Start Codon
4 Dec 2017
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Translation problem set, draw a diagram of dna (you can use two parallel lines) containing one gene. Label where the promoter is located on the dna. Draw the mrna transcript of this gene (take note which dna strand is used as the template). The location of the encoded shine-dalgarno sequence in the strand is underlined. Underline where the missense mutation is located in the sequence. What is the resulting mature peptide sequence of gene b ? (d) suppose gene b has a nonsense mutation due to a substitution of a single nucleotide base, write down a possible dna sequence of this mutated gene b. Underline where the nonsense mutation is located in the sequence. What is the resulting mature peptide sequence of gene b. (e) gene b is in the middle of a 3 gene operon transcribed in the order: gene a, geneb and gene c.
