MCB 2050 Lecture Notes - Lecture 8: Surface 3, Drug Discovery, Chromosome

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 2050
• Professor: Dick Mosser

Document Summary

**genomics** (snustad 7e: ch 15 + 16, pg 431-436: comparative genomics. Mining the information in the genome databases using bioinformatics techniques. Bioinformatics attempts to deduce the structure/function of a gene or gene product through non- experimental (in silico) comparison of genes or genomes. Largely computer modeling of molecules based on the knowledge of sequence, structure, and function of homologues. Genome evolution: documents changes responsible for the divergence of species from common ancestors. Phylogenic trees can be constructed based on sequence comparisons, and from those, evolution can be inferred. The study of genetic and other biological information using computer and statistical techniques. Given a nucleotide sequence: find open reading frames, deduce amino acid sequence, find homology (same structure) to other proteins, find common domains (dna binding, oligomerization, modification sites) Amino acid sequence alignments can identify proteins with related functions. Evolutionary history of the globin gene superfamily: functional genomics.