Class Notes (891,040)
CA (533,044)
U of G (27,752)
NUTR (941)
NUTR 3210 (219)
Lecture 11

NUTR 3210 Lecture 11: micronutrients part 2

6 Pages
84 Views

Department
Nutrition
Course Code
NUTR 3210
Professor
David Mutch

This preview shows pages 1 and half of page 2. Sign up to view the full 6 pages of the document.

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
Micronutrients part 2 micronutrients involvedinoxidantdefense Reduction-Oxidation Reactions Reduction-oxidationreaction aka redox reaction - Involvesthe transfer ofelectrons between two substrates - Many biochemical reactions are essentiallyelectron transfers Large number ofmicronutrients have redox functions The primaryelectron carriersin the body areNADHand FADH2 Thisisimportant for thecreation of ATP Reactive Oxygen Species (ROS) ROSproduced asa by-product of the ETC when proper electron flow fails(~1%leakage) Occursin O2 rich environment where oxygen can react with electrons Radicalshave unpaired electrons - /unpaired electron meansimbalanced electrons - /want toget rid of imbalance sowillget ridof electrons - /radicalsare produced inany cellthat hasa mitochondria Mutations in SOD =Lou Gehrigs - ROSare linked todisease H2O2 converted toH2Oby catalase, glutathione peroxidase (seleniumdependent enzymes) However,ROSarent alwaysbad (remember T3 and T4 production) /1%of electrons from the mitochondria leak outand react withO2which leadstoROS /SODformed by oxygenand electron which isaradical(?) - SODtakesanother electron from copper or zincand willfromH2O2 /ifH2O2 interactswith leaked out electron,it will becomeahydroxyl radical which ishugely reactive - Hydroxylradical will goattack DNA,lipidswhichcan lead tocancer and soforth Vitamin E Encompasses 8compounds(vitamers) - 4 tocopherols o Have saturated side chains with 16carbons - 4 tocotrienols o Have unsaturated sidechains with16carbons Vitamers in both classes (, , , ) Only -tocopherol has significant activity inthebody Nointer-conversion of vitamersin animals Allare found naturally infoods Tocopherol derivedfromgreek word: - Tokos=child birth & phero=tobear orbringforth - Based on work showing that rats couldnt reproducewhen vitaminEwasabsent fromthe diet Vitamin E 4 tocopherols Saturated side chain (phytyl tail) Nomenclature usedto describe #and positionofringCH3groups =most methylated ring ***the hydroxyl group isthe antioxidant side Found free in foods - Found in almonds,dietary plant oils,etc. - Absorbed passively Rand S referstochiralcarbon configurationofmethylgroupsonsidechain Natural -tocopherol isRRR - Fitsin tocopherol transfer protein (TTP) - /most important isnormal -tocopherolRRR sinceit can fit intoTTP - /TTP willmove -tocopherol aroundthe body /differencesimportant inbioactivity in the bodysince methylgroupsareindifferent spots Vitamin E 4 tocotrienols Unsaturated side chain (phytyl tail) Nomenclature rules the same astocopher
More Less
Unlock Document
Subscribers Only

Only pages 1 and half of page 2 are available for preview. Some parts have been intentionally blurred.

Unlock Document
Subscribers Only
You're Reading a Preview

Unlock to view full version

Unlock Document
Subscribers Only

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit