NUTR 3330 Lecture Notes - Lecture 6: Hydroxyl Radical, Bleeding On Probing, Lipid Peroxidation
9 Dec 2016
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Document Summary
Vitamin c and folate: calcium is synthesized from glucose. But we are missing an enzyme which does this (gulunolactone oxidase) because the gene to code for it is mutated. Metabolic roles of vitamin c: ascorbic acid is a reducing agent - keeps things in their reduced form. Collagen is the largest protein in the body. For it be synthesized proline and lysine has to be hydroxylated. This hydroxylation requires iron as a cofactor in its reduced from (ferrous +2). Vit c keeps iron in its reduced form therby allowing it act as a cofactor in hydroxylation of proline and lysine residuses allowing collagen synthesis to occur. Role in carnitine synthesis / fa oxidation. For fatty acid axoidation it must be transported into mitchondira via carnitine shuttle. Carnitine shuttle is synthesized from methionine and lysine, both of wich are dependant on iron. Iron has to in reduced form to hydroxylated them. And vit c keeps iron in reduced form.
