NUTR 3360 Lecture 4: Where have we gone since the Human Genome Project? - Continued

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Variation in a single nucleotide that occurs at ta specific position in genome: most common type of genetic variation among humans. Remember the hapmap project: occur normally, once ever ~300 bp = ~10 million snps in the human genome, occur more frequently in non-coding vs. coding dna, biological markers of disease susceptibility. 1387 european participants genotyped for 197 146 snps. Despite low average levels off genetic difference among participants, there was a close correspondence between genotype and country of origin: participants could be tracked back within ~400 km of their country of origin based on snps. Major populations are distinguishable by snps: close correspondence between genotype and language within a country, major populations are distinguishable by snps! Snps in fto and mc4r genes are strongly associated with bmi and obesity (or = 1. 1-1. 3) Tage (cid:1005) of gwa for bmi i(cid:374) (cid:1007)(cid:1006)(cid:1007)(cid:1012)(cid:1011) parti(cid:272)ipa(cid:374)ts of europea(cid:374) a(cid:374)(cid:272)estr(cid:455) .

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