NUTR 4040 Lecture 19: Alzheimer Disease

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29 Nov 2017
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Plaques- tiny deposits of waxy amyloid proteins that become toxic to brain cells. Neurofibrillary tangles- in cytoplasm of neuron interrupt transport of nutrients. The # of plaques and degree of cell loss are positively correlated with severity of dementia. Focuses on increasing acetylcholine relay messages between neuron. Dying out because the cells that are producing it are dying and is degraded by cholinesterase. Relatively new drug is ebixa= works by keeping glutamate away and not overloading. Glutamate is toxic to neurons (glutamate neurotransmitter that helps with learning and memory) Nutrition cannot prevent ad, but it can help support the patient by preventing wt. loss, manage swallowing difficulties and improve quality of life. Early stage of ad (forgetfulness, impaired shopping, food preference change, wt. loss common) Provide well-linked and well-balanced meals and snacks in a cheerful, relaxing atmosphere. Min confusion, offer ready to eat and bite sizes pieces.

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