NUTR 4210 Lecture Notes - Lecture 10: Immunotherapy, Adipose Tissue, Pancreatic Cancer

• School: University of Guelph
• Department: Nutrition
• Course: NUTR 4210
• Professor: Lindsay Robinson

Document Summary

Physical activity & cancer: physical activity can improve cancer-related symptoms, reduce skeletal muscle loss, reduce nausea, reduce fatigue. Improve quality of life: mood, self-esteem, retain physical capabilities, reduce dependence on others for help with activities of daily living. Soluble tnf receptors (not talking about body) Tnf-a is(cid:374)"t a(cid:448)aila(cid:271)le to ta(cid:396)get skeletal (cid:373)us(cid:272)le in promoting catabolism. Glut-4 synthesis gets glucose out of the blood and into the muscle, this is important for hypoglycemia. Pi-3-k expression insulin mediated pathway for glucose transport into the muscle. Nutr*4210: we"(cid:396)e (cid:373)o(cid:396)e (cid:272)o(cid:374)(cid:272)e(cid:396)(cid:374)ed a(cid:271)out ta(cid:396)geti(cid:374)g a(cid:374)(cid:455)thi(cid:374)g that (cid:272)a(cid:374) help us slo(cid:449) do(cid:449)(cid:374) the loss of muscle protein. In cancer cachexia, any type of physical activity is going to be good: strength and resistance exercise is going to be particularly important. Nutr*4210: helps to maintain independence, higher il-10 and il-1ra levels, higher receptor levels to bind il-1, so wont be inflammatory, decreased tnf- levels.