NUTR 4210 Lecture Notes - Lecture 9: Lactate Threshold, Cell Membrane, Protein Kinase B
7 Mar 2016
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Lecture 4: integrative metabolism : cho: plasma derived substrates (glucose, fa, endogenous substrates (glycogen, triglycerides) Same basic points about fuel sources in exercise. Supply most of the energy at low intensity exercise. How does fuel get used during exercise. 3rd step used f16bpase to convert f6p to f16bp. It ends up in the liver, the heart can take up lactate converted to pyruvate and used aerobically to produce atp. It is used in the liver for glucconeogenesis (cori cycle: substrate level phosphorylation. Glycolysis and gng inhibit eachother lactic acid builds rapdily. It can be converted back to pyruvate and used to generate atp in aerobic pathways. Lactate threshold (lt) training status: the cori cycle has a net loss of 4 atp. It is key to remember that muscle doesn"t have the enzymes capable of gluconeogensis from lactate there is no biochemical support for lactate production causing acidosis.
