NUTR 4320 Lecture Notes - Lecture 11: Tissue Transglutaminase, Coeliac Disease, Gliadin
8 Mar 2019
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Treatment: gluten free diet - for life: only current available treatment: lifetime avoidance of all gluten containing foods. Genetic component: hla-dq2 or hla-dq8 is not sufficient: diagram depicting the distribution of hla-dq2 and dq8 in the general population and in patients with celiac disease. Almost 100% of patients with celiac disease express either hla-dq2 (90%) vs. Hla-dq8 or dq7 (10% - rare), making either allele necessary for the development of celiac disease. However hla-dq2, dq8, and dq7 are common in the general population, even in healthy subjects: most people with cd will be in dq2 form. Ttg comes in and removes amine group to make glutamate with negative charge which has stronger binding affinity of. Immune response generated from apc and cd4+ t cell interaction to make th1 proliferate (1->100 t cells) Phase 1: uptake and processing of gluten peptides: 1.
