PATH 3610 Lecture Notes - Lecture 3: Passive Immunity, Gallstone, Fibrinogen

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Rob Foster

Document Summary

Located right below the diaphragm and anchored. Should not be able to feel the liver during physical exam, otherwise it is too big. Drugs such as alcohol, tylenol are bad for the liver. Non narcotic analgesics, also inhibit cox2 at high doses. The only product form coal tar that is not carcinogenic. Max dose = 4g (8 extra strength tylenol) Toxic dose with alcohol 2. 5g (5 es + 3-4 drinks) Could easily end up with liver failure if taking tylenol and alcohol at the same time. High volume of blood supply but low pressure. So a slight change in p will dramatically change the effect. Portal vein (from intestine to bring nutrient (exp fat) Supply blood to the channels (sinusoids) that run between hepatocytes. Then blood goes to the central vein and go to the heart. Stable cell type = regenerate if needed. Modified capillaries, lined by endothelium with gaps between cells.