PATH 3610 Lecture Notes - Lecture 8: Tight Junction, Natural Killer Cell, T Helper Cell
27 Mar 2018
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Document Summary
Multipotent (more than one cells type), self-renewing progenitor cells. Cd4+ t helper cells: th1, 2, 17, treg. Irregular shaped nucleus (lymphocytes have big round nucleus) Direct harm to pathogens by phagocytosis and activation of bactericidal mechanisms. Attracted by chemokines produced by other leukocytes. Some hypothesize that mast cells are mature basophils. Mainly involved in parasitic responses by releasing granules. Larger granules than neutrophils because it is their only weapon. Circulate in blood, can move to tissues. Produce cytokine to signal what type of inflammation if happening and what should be done. Damage the membrane of parasites = allergic reaction more than anti-parasitic. Killing of antibody coated parasites, antiviral and anti-parasitic activity. Migrate into tissues and then differentiate into macrophages and dendritic cells. Slower, patrol the environment, roll along blood vessels. Can enter the tissue (act like a reservoir) Phagocytosis, activation of bactericidal mechanisms and antigen presentation. Present antigens as apcs via hmc complex.
