PATH 3610 Lecture Notes - Lecture 6: Dendritic Cell, Chemokine, Neutrophil
14 May 2018
School
Department
Course
Professor
Healing
Inflammation, healing and repair
- injury to cell – initiating event to repair process
- damage and microbial injury initiated the process and cause release of
damage associated molecular patterns (DAMP) or microbial associated
molecular patterns (MAMP) that are recognized by macrophages, dendritic
cells or neutrophils by Toll-like receptors (TLR), c-type lectin receptors
(CLR) and other receptors
- results in release of inflammatory cytokines
o repair begins immediately within seconds
o form of repair is dependent on
▪ the extent of the damage
▪ the tissue
▪ host factors
- Inflammation phase: where injurious substance is neutralized or removed
and sets reconstitution
o Divide into acute and chronic
▪ Acute: lasts mins to days, dominated by components of plasma
and neutrophils
▪ Chronic: much longer, dominated by lymphocytes, plasma
cells and macrophages and usually has an element of fibrosis
o Inflammation driven by chemical mediators(chemokines)
▪ Responsible for orchestrating, controlling and resolving the
response
o Clinical signs based on cardinal signs:
▪ Rubor or redness
▪ Tumour or swelling
▪ Calor or heat
▪ Dolor or pain
▪ Loss of function
- Repair: is this reconstitution of the damaged tissue by regeneration of the
original tissue, or replacement of tissue with fibrous tissue (scaring)
- Basic components of inflammation = plasma and WBC
- Plasma: fluid fraction of blood that includes
- dendritic c
Inflammation and Healing
Overall Scheme in healing
- stimulus – injury
o direct injury
o damage-associated molecular patterns (DAMPs): when there is
damage to tissue
o Pathogen-associated molecular patterns (PANPs): pathogen is an
infectious agent that cuases disease
- Local response
o Primitive response is phagocytosis and hypertrophy/pyperplasis
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