PATH 3610 Lecture Notes - Lecture 17: Gastric Mucosa, Muscularis Mucosae, Gastric Glands
14 May 2018
School
Department
Course
Professor
Digestive system
Stomach, SI
- gastric erosion and ulceration
o erosion: loss of gastric mucosa b/c death of epithelium
o ulcer: deep erosion that penetrates the muscularis mucosa
- peptic juices in stomach: HCL and pepsin – secreted by gastric glands
(foveolae)
o protein digestion and kills unwanted microbes
o mucus secreted by outer lining and protects from autodigestion
- most nutrient absorption in SI and fluid absorption in LI
Signs of Gastric abnormality
- pain (dyspepsia)
- heartburn (acid reflux, gastroesophageal reflux – GERD)
- vomiting (emesis hence antiemimetic)
- Melena: latin = melon (means black, dark)
o Means dark tarry feces
- Ulcer: cell death of the lining of epithelial structure
o Gastric ulcers: gastric mucosa = folds that helps stomach expand
o Ulceration – imbalance between mucosal defence and aggressive
forces
▪ Normal forces: acid and pepsin
Stomach – ulcers
- gastric ulcer – stomach, leads to perforation, haemorrhage, obstruction and
pain
- Duodenal ulcer – duodenum (most common)
- Peptic ulcer – peptic juice
- Complications
o Pain
o Perforation
o Haemorrhage
o Obstruction
Normal stomach (refer to diagram)
- lots of glands in the surface of stomach
- little columns of fluid (acids) squirted into the lumen
Pathogenesis
- protective forces
o mucus
o bicarbonate – buffers the acid → acid goes to tissue and bicarbonate
to fluid
o jets of acid and pepsin
o regenerative capacity
o prostaglandins
▪ blood flow
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Document Summary
Digestive system (foveolae: protein digestion and kills unwanted microbes, erosion: loss of gastric mucosa b/c death of epithelium, ulcer: deep erosion that penetrates the muscularis mucosa. Peptic juices in stomach: hcl and pepsin secreted by gastric glands: mucus secreted by outer lining and protects from (cid:498)autodigestion(cid:499) Heartburn (acid reflux, gastroesophageal reflux gerd) Melena: latin = melon (means black, dark) Most nutrient absorption in si and fluid absorption in li. Signs of gastric abnormality: means dark tarry feces forces, normal forces: acid and pepsin. Ulcer: cell death of the lining of epithelial structure: gastric ulcers: gastric mucosa = folds that helps stomach expand, ulceration imbalance between mucosal defence and aggressive. Gastric ulcer stomach, leads to perforation, haemorrhage, obstruction and. Complications pain: pain, perforation, haemorrhage, obstruction. Normal stomach (refer to diagram) lots of glands in the surface of stomach little columns of fluid (acids) squirted into the lumen.
