POPM 4040 Lecture 9: POPM 4040 Lecture : Campylobacter

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Gram-negative bacteria c. jejuni is the most frequently reported from human cases followed by c. coli o. C but survives well at refrigerator temperatures (4. Sensitive to freezing, drying, acidic conditions and salinity. C. jejuni and c. coli both grow at 420c: microaerophilic: requiring a lower o (3-15%) and a higher co ( 3-5%) 2 concentration than is present in the atmosphere. Adherestoenterocytes producetoxinandinducesdiarrhea: penetratethegimucosabyusingits high motility and spiral shape, c. jejuni release several toxins, mainly enterotoxin and cytotoxins, toxins vary from strain to strain, and are associated with the severity of the enteritis, pathogenicity is also strain-related. Incubation: 2-7 days: clinical signs, headache, fever, nausea, sometimes vomiting, cramping and abdominal pain, diarrhea, bloody stools(8-10bms/day, +/-bacteremia, chronic diarrhea of immune compromised. Duration: ~ 1 week (9 days) self limiting: but shed bacteria for days to weeks after symptoms end. Campylobacteriosis: complications pancreatitis, peritonitis, massive gi hemorrhage.

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