PSYC 2330 Lecture Notes - Glutamine, Excitatory Postsynaptic Potential, Nmda Receptor

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Published on 10 Oct 2012
School
University of Guelph
Department
Psychology
Course
PSYC 2330
Thursday April 5, 2012
PSYC*2330 Lecture 20
- e.p.s.p = excitatory post-synaptic potential
- all have the same response so the strength of this synapse is all the same
- first test number 1 by stimulating then record, then later test number 2 and record and
then test number 3 and record
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- number 3 is not stimulated at all (silent) - no action potentials are produced
- the other 2 inputs are stimulated artificially, one very intensely (a train of stimulation)
and the other one just mildly but at the same time
- do this a few times, this is where you induce longterm association and then come back
and test them the same way you did before
- when you test 3, the response you get now is completely identical as before
- the other 2 change
- not surprising that number 1 has been amplified because it was intensely stimulated
- LTP occurs in the 2nd one
- neuron 2 was weakly stimulated so it shouldnʼt have changed
- because it happened at the same time as the first one was stimulated it changed
- only inputs active at the same time and one of them that is really strong will change
- strong stimulation of synapse 1 induced LTP in synapse 2 because it was active at the
same time
Glutamate
- Glutamate is an amino acid, used in the brain to produce excitation
- Principle excitatory neurotransmitter of the brain & spinal cord
- Four types of receptors but only 2 will be discussed
- when glutamate is released it will act on one side of the receptor and if it attaches itself
the receptor will open and glutamate will go in and excitation happens
1. NMDA receptors 2. AMPA receptors
- AMPA receptors usually mediate regular excitation (regular workers)
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Document Summary

All have the same response so the strength of this synapse is all the same. Rst test number 1 by stimulating then record, then later test number 2 and record and then test number 3 and record. Number 3 is not stimulated at all (silent) - no action potentials are produced. The other 2 inputs are stimulated arti cially, one very intensely (a train of stimulation) and the other one just mildly but at the same time. Do this a few times, this is where you induce longterm association and then come back and test them the same way you did before. When you test 3, the response you get now is completely identical as before. Not surprising that number 1 has been ampli ed because it was intensely stimulated. Neuron 2 was weakly stimulated so it shouldn t have changed. Because it happened at the same time as the rst one was stimulated it changed.

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