Class Notes (810,969)
Canada (494,410)
Psychology (3,830)
PSYC 2330 (214)

PSYC*2330 Lecure 20.pdf

6 Pages
Unlock Document

University of Guelph
PSYC 2330
Francesco Leri

Thursday April 5, 2012 PSYC*2330 Lecture 20 - e.p.s.p = excitatory post-synaptic potential - all have the same response so the strength of this synapse is all the same - first test number 1 by stimulating then record, then later test number 2 and record and then test number 3 and record - number 3 is not stimulated at all (silent) - no action potentials are produced - the other 2 inputs are stimulated artificially, one very intensely (a train of stimulation) and the other one just mildly but at the same time - do this a few times, this is where you induce longterm association and then come back and test them the same way you did before - when you test 3, the response you get now is completely identical as before - the other 2 change - not surprising that number 1 has been amplified because it was intensely stimulated - LTP occurs in the 2nd one - neuron 2 was weakly stimulated so it shouldnʼt have changed - because it happened at the same time as the first one was stimulated it changed - only inputs active at the same time and one of them that is really strong will change - strong stimulation of synapse 1 induced LTP in synapse 2 because it was active at the same time Glutamate - Glutamate is an amino acid, used in the brain to produce excitation - Principle excitatory neurotransmitter of the brain & spinal cord - Four types of receptors but only 2 will be discussed - when glutamate is released it will act on one side of the receptor and if it attaches itself the receptor will open and glutamate will go in and excitation happens 1. NMDA receptors 2. AMPA receptors - AMPA receptors usually mediate regular excitation (regular workers) NMDA receptors - critical to induction of longterm association - difficult to open, doesnʼt open by itself, it has a lot of bindings sites not just for glutamate - if glutamate is released it will try to open the receptor and it will change a bit but not much because Magnesium is a bad molecule blocking the channel - if you just use glutamate it wonʼt open - also beside magnesium is a site for PCP, angel dust or ketamine you will experience outer body image usually related to the sense that you can go through doors and holes and change the shape of your body Symptoms of PCP: altered body image, feeling of isolation, drowsiness, negativism & hostility, euphoria, dreamlike state, psychosis (30 days), seizures & death - normally there is no drug lodged in there so this only happens if we take the drug - the question is
More Less

Related notes for PSYC 2330

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.