PSYC 2410 Lecture Notes - Lecture 1: Nerve Growth Factor, Neural Plate, Neurotrophin

• School: University of Guelph
• Department: Psychology
• Course: PSYC 2410
• Professor: Elena Choleris

Document Summary

Embryotic development -> postnatal childhood development -> adulthood a fixed organ. Cns continues to change throughout entire life -> brain plasticity. After formation cells need to: differentiate, migrate to the appropriate location, establish functional relations with other cells. Totipotent: early embryonic cells, can differentiate in any cell type of the body. Cells can still become many, but not all, cell types. Multipotent: cells that can develop into multiple cell types within a class of cells. Unipotent: cells that can only complete their differentiation into one cell type. Stem cells: two properties: unlimited divisions without differentiation, potential to differentiate into different cell types. 1: neural proliferation, migration and aggregation, axon growth and synapse formation, neuron death and synapse rearrangement. Regulated by chemical signals from the floor plate (along ventral surface) and roof plate (dorsal surface of the neural tube) Migration and aggregation: glial mediated locomotion, somal translocation. Guided by chemicals that either attract of repel migrating cells.