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Lecture 2

PSYC 2650 Lecture Notes - Lecture 2: Visual Cortex, Magnetic Resonance Imaging, Transcranial Magnetic Stimulation

Course Code
PSYC 2650
Anneke Olthof

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Video: because he is having no physical reaction when he sees them, his brain tells him that the people are not people
he knows.
Principal Structures of the Brain
- Different parts of the brain do different things; and when they get damaged they can do weird things.
- The simplest fact illustrated by Capgras syndrome is that different parts of the brain perform different jobs.
- Researchers began to realize this in the nineteenth century by studying the cognition and behaviour of patients
with lesions to the brain.
Phineas Gage was one such famous patient. In 1848, an explosion during the construction of a railway sent a tamping
iron through his frontal lobes, resulting in a variety of cognitive and emotional changes; after the accident his personality
had completely changed; he seemed to have lost the part that told him what was inappropriate (acted on animal
instincts and could not make decisions).
- The study of people with brain lesions help us learn about the function of these brain regions in healthy people;
the approach is referred to as the localization of function.
- Even for simple cognitive tasks, multiple regions are involved; one area isn’t responsible for one certain thing.
- One of the first areas to develop, one of the oldest parts
- Sits directly atop the spinal cored
- Control rhythms of the heart and breathing
- Regulates levels of alertness
- Includes cerebellum which coordinate movement and balance, in addition to more recently discovered sensory
and cognitive roles (ex. finding short cuts).
- Sits above the hindbrain
- Coordinates movement, especially eye movement
- Includes parts of auditory pathways (from ears to parts of forebrain)
- Regulates experience of pain
- The rest of the brain
- Most of what you see when you look at the brain
- Includes the cortex (outer layer of thin convoluted sheet of tissue, 3mm thick)
- A variety of subcortical structure
Cortex: divided into left and right cerebral hemispheres by the longitudinal fissure; commissures are
thick bundles of nerve fibers that connect the two hemispheres; the largest one is corpus callosum; the cortex is divided
into anterior and posterior regions by the central fissure.
Frontal lobes: whole part of the brain
Parietal lobes:
Temporal lobes: processing auditory information
Occipital lobes: visual information

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Subcortical Parts
Thalamus: every sense except smell; sensory information goes
through here for processing
Hypothalamus: motivated behaviours (eating, sleeping, sex)
Limbic system: Amygdala (emotional); hippocampus (new
information; H.M. frozen in time had no hippocampus)
Recall that neuroimaging allows researchers to take high quality, 3D images of the living brain; takes x-ray slices and
assimilates all the slices into an image.
Computerized axial tomography (CT): good for getting brain structure
Positron emission tomography (PET): better for brain function; has a way of measuring blood flow
Magnetic resonance imaging (MRI): good for structure; uses magnets and measures magnetic properties
of cells in your brain; can plot of variations.
Functional magnetic resonance imaging (fMRI): good for brain function; measures where the blood is
flowing when you are doing various tasks; also uses magnets.
Ex. fMRI study:
When viewing images of faces, the fusiform face area (FFA) is active.
When viewing images of houses, the parahippoccampal place area (PPA) is active
Binocular rivalry: showed that the activation in these two regions reflects what the
person is conscious of; not just the presented stimuli.
*note that the regions indicated by fMRI studies are not always necessary for the task in question; instead they may only
be correlated with the task, in the way a speedometer is correlated with (but not needed for) the movement of the car;
ex. you can still have those areas active, but may not be the part of the brain that is processing
Transcranial magnetic stimulation (TMS): used to ask whether an area of the brain is necessary; knock out a part of the
Primary projection areas: primary arrival and departure points for information entering (sensory areas) and leaving
(motor areas) the cortex; located in the posterior frontal lobes; more cortical space is devoted to the regions of the body
we move with the greatest precision; right side is controlling left and left is controlling right.
The primary somatosensory projection area is located in
the anterior parietal lobes.
The primary auditory projection area is located in the
superior temporal lobes.
The primary visual projection area is located in the
occipital lobes.
The cortical maps represent sensory or motor information in
an orderly manor; organization is by region of the body,
region in space or auditory frequency. Cortical space is assigned disportionately; greater sensory acuity or motor
precision is associated with larger cortical representation. Cortical organization is contralateral; the left side of the body
or perceptual world has more representation on the right side of the brain, and vice versa.

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The rest of the cortex has been considered association cortex.
Neurological syndromes that reflect damage to regions of the association cortex include:
Apraxia problems with the initiation or organization of movement
Agnosia problems identifying familiar objects
Aphasia problems with language
Neglect syndrome problems in which half of the visual world is ignored
Prefrontal damage problems with planning and implementing strategies, inhibiting behaviours
Vision is the modality through which much of our knowledge is acquired. Vision provides an excellent illustration of how
the close study of the brain can proceed, and what it can teach us. The structure of the eye is designed to project a sharp
image onto the retina, the light-sensitive tissue that lines the back of the eye.
Two types of photoreceptors are cells respond to light and are
found on the retina:
1) Rods
- Higher sensitivity
- Lower acuity
- Colour-blind
- Found in the periphery of the retina
2) Cones
- Lower sensitivity
- Higher acuity
- Colour-sensitive
- Found in the fovea
A series of neurons communicates information from the retina to the cortex.
- In the eye:
o Photoreceptors
o Bipolar cells
o Ganglion cells and the optic nerve
- In the thalamus:
o Lateral geniculate nucleus (LGN)
- In the cortex:
o V1, the primary visual projection area, or primary visual cortex, located in the occipital lobe; back of the
Much of what we know about the visual system comes from a technique known as single-cell recording; to understand
this technique, we need to learn a few things about neurons.
The basic parts of a neuron are:
- Dendrites, which detect incoming signals
- The cell body, which contains the nucleus and cellular machinery
- The axon, which transmits signals to other neurons
Communication between neurons is done via chemical signals.
Neurotransmitters are chemicals released by one neuron to communicate with another neuron.
The space between the two is called a synapse; thus, the first neuron is called the presynaptic
neuron and the second neuron the postsynaptic neuron.
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