PSYC 2650 Lecture Notes - Lecture 8: Neurofibrillary Tangle, Amyloid, Capgras Delusion

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Build-up of neurofibrillary tangles and amyloid plaques. Pla(cid:395)ues a(cid:374)d ta(cid:374)gles (cid:862)choke off(cid:863) (cid:374)eu(cid:396)o(cid:374)s, killi(cid:374)g the(cid:373) Ad can only be formally diagnosed post-mortem. Post-mortem analysis often fins plaques and tangles present in asymptomatic individuals. Neurodegeneration often beings in medial temporal lobe structures. Pathological changes can begin 10-20 years before symptoms appear. Degeneration spreads to other cortical areas, yielding additional cognitive impairment as disease progresses. Belief that a person, place, or thing well known to the patient has changed identity. These are delusional beliefs: unsubstantiated by reality, not shared by other people, and resistant to counterevidence and counterarguments. When in relation to well-known people (e. g. spouse) referred to as (cid:862)capg(cid:396)as sy(cid:374)d(cid:396)o(cid:373)e(cid:863) (cs) Patient: no you are not, you just look like her get out of here or she will be mad. Traditionally cs was associated with psychiatric illness, focal brain lesions, or cerebrovascular disease. Normal familiar person recognition vs. in capgras syndrome.

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