PSYC 3030 Lecture Notes - Lecture 10: Nucleus Basalis Of Meynert, Raphe Nuclei, Muscarinic Antagonist

• School: University of Guelph
• Department: Psychology
• Course: PSYC 3030
• Professor: Boyer Winters

Document Summary

Central cholinergic systems: interneurons of the striatal complex (striatum) Large, aspiny (lacking dendritic spines) ach neurons which serve as interneurons. In the caudate-putamen, there are medium sized spiny ach output neurons. Within the striatum there are output neurons, medium size, project to the neuro-cortex, but the majority are interneurons (short axons) Interneurons manage local communication to and from the striatum: projection neurons of the cholinergic basal forebrain. Rostral basal forebrain: (ch1-) medial septum (ch2-) vertical limb of the diagonal band of broca. Medial basal forebrain: (ch3-) horizontal limb diagonal band of broca. Caudal basal forebrain: (ch4-) nucleus basalis and substancia innominate. Projectly mostly to the amygdala and neo-cortex (prefrontal, parietal, etc. ) Dopaminergic projection neurons from the brain stem terminate in the striatum, important for functioning of neurons there. Activated by a lot of arousing stimuli important in learning and memory. Chat and parvalbumin ihc in the rat basal forebrain. D: nucleus basalis, etc: pontomensencephalic cholinergic cell groups.