PSYC 4470 Lecture Notes - Lecture 13: Knockout Mouse, Perirhinal Cortex, Nifedipine
2 Mar 2017
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Lasting ltp more relevant to salient induction patterns, high frequency stimulation patters or more salient experiences, induce transcription in the nucleus (inducing calcium to cascade messengers, activating camp, ac, camkii, calmodulin creb. Two objects delay (15 min, 24 hr) sample object vs. novel object testing discrimination ratio. Injecting a virus to inhibit creb (rna interference creb (cid:272)a(cid:374)"t (cid:271)e produ(cid:272)ed i(cid:374) perirhinal cortex and prevents object memory formation) Creb was important for ltm in the perirhinal cortex but not stm. Right object right eye left hemisphere. Left object left eye right hemisphere. Fos (protein product) stained non-selective, (neurons who have been recently activated by behavioural stimuli have expressed fos), predicted there would be more. Fos+ cells in the novel objects vs. familiar: rats act as their own controls the same rat is used for each condition, same brain/2 hemispheres/2 conditions. Count black dots of activation te (ventral visual stream), prh, ent, occ, v1, prh, sc,
