ZOO 3050 Lecture Notes - Lecture 19: Sonic Hedgehog, Neural Crest, Neural Tube

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A-p neural tube patterning i: at end of gastrulation embryo starts elongating, this is setting up ap and dv axis. In the very early undifferentiated tube if you take a piece of this interface and place it into a naive embryo you can induce the development of this region. A-p neural tube patterning ii: two major morphogens in this isthmic region, wnt1/fgf8, type of signalling is being conserved but the specificity is not, don"t need to memorize diagram just know circled part, hindbrain/midbrain. These secreted factors are also expressed in the hindbrain region. Sonic hedgehog is expressed in the spot where the neural tube is forming (d-v patterning). Important: if you look at this you will find that it is much conserved between vertebrates. Ectodermal cells that ultimately lead to the production of migrating cells. Migrate to the embryo, happening when neural tube is separated from the ectoderm.

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