ZOO 3050 Lecture Notes - Lecture 22: Ureteric Bud, Intramembranous Ossification, Endochondral Ossification
5 Feb 2018
School
Department
Course
Professor
Document Summary
Initiates the precursor to bone: intramembranous ossification, cartilage, endochondral ossification, main skeletal bones, main differences of the two are their outcomes, kidney development, 3 stages, pro, meso, meta. If you remove the mesenchymanl cells, you don"t get a nephron or the branching of the bud. Kidney formation as a model for organogenesis: with knock out mice, remove some of these genes to figure out their functions, help understand developmental defects at birth that could help reverse/heal the problems quickly. Limb formation is not essential for embryonic life: polydactyl, can also get cases where the function of the digit has changes (thumb replaced with another. Regular finger: syndactyl, fusion of digits (webbing) Vertebrate limbs: strong homology across vertebrates, vertical limbs are built similarly even if they look different. 3 axis of limb development: a-p (axis 1) A-p (axis 2_ in limbs (thumb pinky axis: proximal-distal axis (elbow hand, d-v axis.
