BGEN 3020 Lecture Notes - Immunoglobulin M, Immunoglobulin G, Appendicitis

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

When you have non-tender, think malignant, either (1) mets or 2) primary lymphoma originating from it. Always tell if painful/less: localized vs. generalized lymphadenopathy: localized (ie exudative tonsillitis goes to local nodes; breast cancer goes to local nodes. Follicular lymphoma = mc non-hodgkin"s lymphoma: b-cell; translocation 14,18; and apoptosis gene knocked off, so the cells are immortal. Example: plaque like lesions, no teeth, not a fungal infection actually the inflammatory cells are really neoplastic; so the helper t cell in mycosis fungoides is neoplastic, therefore it"s a t cell malignancy. Involves the skin and lymph nodes vs. sezary cell syndrome which is seen in peripheral blood (malign helper t cell that is in peripheral blood, in mycosis fungoides) Painful lymphadenopathy = some type of inflammatory condition, not malignant. Painless lymphadenopathy = malignancy: mc malignancy of lymph node = metastasis. Mc primary cancer of lymph node = non hodgkin"s lymphoma: follicular b cell lymphoma (translocation: 14, 18.