BGEN 3020 Lecture Notes - Coagulation, Amylase, Hypercalcaemia

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

Problems related to problems related to oxidative pathway: most imp: cytochrome oxidase (last enzyme before it transfers the electrons to o2. Remember the 3 c"s cytochrome oxidase, cyanide, co all inhibit cytochrome oxidase. You only want protons to go through a certain pore, where atp synthase is the base, leading to production of atp; you don"t want random influx of protons. And that is what uncoupling agents do. Examples: dinitrylphenol (chemical for preserving wood), alcohol, salicylates. Uncoupling agents causes protons to go right through the membrane; therefore you are draining all the protons, and very little atp being made. B/c our body is in total equilibrium with each other, rxns that produce protons increase (rxns that make nadh and fadh, these were the protons that were delivered to the electron transport system). Therefore any rxn that makes nadh and fadh that leads to proton production will rev up rxns making nadh and fadh to make more protons.