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BIOL1412 03 26 2014.docx

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Department
Biological Sciences
Course
BIOL 1412
Professor
Paul Messing
Semester
Winter

Description
BIOL1412 03 26 2014 iii. proteins ­ HCl (parietal cells) ­ denatures proteins + acts on pepsinogen Pepsinogen (inactive) HCl to start, then pepsin           (+ve feedback) Pepsin (active) Proteins                            peptides, amino acids  stomach protected from self­digestion by alkaline mucous (mucous cells) 2) Absorption  food = very little (if any)  some drugs ­ alcohol, aspirin (penetrate mucous) Small Intestine 1) Digestion a. mechanical ­ segmentation and peristalsis b. chemical ­ involves: i. pancreas ii. gall bladder iii. intestinal wall (Fig. 23.1)  steps: (Fig. 23.21)  Step 1: Neutralize Acid (so pancreatic enzymes can work)  alkaline fluid (HCO3­) ­ duct cells of pancreas and gall bladder  regulation: acid in duodenum ⇑ secretin (hormone)                                                           3­                               ⇓ gastric acid                                             (duct cells)                              secretion (parietal cells  Step 2: Pancreatic Enzymes (into intestinal lumen from pancreatic acinar cells): i. carbohydrates polysaccharides                            disaccharides    +    oligosaccharides                                                pancreatic amylase   (eg. maltose) ii. proteins (Fig. 23.27) ① trypsionogen                                 trypsin                                                                      enteropeptidase on                                                                      intestinal wall ② trypsin activates proteases:                                                 Inactive           trypsin             Active trypsinogen                              trypsin (+ve feedback)                                                                         typsin chymotrypsinogen                 chymotrypsin                                                                            trypsin procarboxypeptidase                carboxypeptidase                                                                proteases (active) ③ dietary +                            peptidase +                                                 secreted proteins                  amino acids iii. fats (lipids)                                                                      lipase triglycerides                        fatty acids    +    monoglycerides                                                                (with bile salts)  Regulation of pancreatic enzyme secretion: 
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