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BIOL1412 03 28 2014.docx

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Department
Biological Sciences
Course
BIOL 1412
Professor
Paul Messing
Semester
Winter

Description
BIOL1412 03 28 2014 Note: MBIO1220 A01­A03 Exam ­ April 25th @ 9:00 AM @ FR Kennedy Gold Gym Small Intestine 2) Absorption  absorbed nutrients go: a) to liver via hepatic portal vein (blood) (Fig. 19.19) b) into lacteals (lymph) ⇒ thoracic duct ⇒ left subclavian vein (Fig. 23.22) (Fig. 20.2) 3) Fat Digestion + Absorption  requires bile from:  liver (synthesizes)  gall bladder (stores) (Fig. 23.21)  bile consists of:  water  bile salts (derived from cholesterol)  bile pigments (bilirubin from RBC breakdown  ions (HCO3­)  detoxified/ inactivated drugs, toxins, hormones, etc.  functions of bile salts: a) emulsification ­ breaks up larger globules of fat into many small droplets (Fig. 23.34) b) micelle formation ­ keeps fat digestive products in solution  micelle = bile salts + phospholipids  interior = hydrophobic  exterior = hydrophilic  in lumen: (Fig. 23.34) lipid globule          emulsification, lipase fatty acids + monoglycerides diffuses into enterocyte FA, MG diffuse from micelle into enterocyte  in enterocyte: MGs + FAs (in SER)    enzyme diglycerides + FA (in SER)    enzyme triglycerides             cholesterol, proteins, phospholipids added in golgi chylomicron (fat + protein package = water soluble)                  exocytosis ISF     diffusion lymph (lacteal) Gastric Motility/Secretion  3 regulatory phases: 1) Cephalic Phase  preparing stomach for food  triggers = thought, sight, smell, taste of food                  NS (enteric + PSNS) ⇑ enzymes  ⇑ gastrin ⇑ acid ⇑ smooth  (pepsinogen +             (hormonesecretion             muscle motility lipase) 2) Gastric Phase food in stomach ­ distension activates stretch receptor same as Cephalic Phase *Ca+2, aa, peptides alcohol, caffeine, (can increase gastrin release)  food = buffer ­ pH ⇓ slowly; reaches 3 when stomach nearly empty  when pH 
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