BIOL 2520 Lecture Notes - Lecture 15: Myosin, Kinesin, Intermediate Filament

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2520
• Professor: stout

Document Summary

Motor proteins of the cell convert chemical energy stored in the form of atp into mechanical energy that is used to: generate force, move cellular cargo attached to the motor. Types of cellular cargo: ribonucleoprotein particles, vesicles, organelles (mitochondria, lysosomes, chloroplasts, chromosomes, other cytoskeletal filaments. A single cell may contain dozens of different motor proteins, each specialized for moving a particular type of cargo in a particular cell region. Motion is a bit like rope-climbing or swimming: alternate between power strokes and recovery strokes: o, 1 atp burned for each stroke. Cells have three families of motor proteins: kinesins, move towards the (+) end of the microtubule, dyneins, move towards the (-) end of the microtubule. Kinesins and dyneins move in opposite directions. They can attach to different adapter proteins. The adaptor proteins then attach to proteins imbedded in the vesicle membrane, the cell membrane, or the adjacent microtubules to generate movement: myosins, a microfilament motor protein.