MBIO 2360 Lecture Notes - Lecture 5: Threonine, Aspartic Acid, Tyrosine
1 Dec 2016
School
Department
Course
Professor
Document Summary
Review - stereochemistry: molecular conformation refers to differences in spatial arrangement of groups joined by covalent bonds due to bond rotation, molecular configuration refers to isomers that can be interconverted only by breaking bonds. Isomers have the same molecular formula but a different arrangement of the groups. Ex - leucine and isoleucine: there are 4 different substituents on the alpha carbon when (r is not h) allowing the existence of mirror images or chiral isomers. Ex - d-glyceraldehyde (oh on right or dextro) and l-glyceraldehyde (oh on left or levo: for amino acids, the aldehyde is replaced by carboxyl. The ch2oh is replaced by the various r groups and the oh by nh3. Ex - d-serine and l-serine: most naturally occurring amino acids are in the l- isomeric form, the alpha carbon is the chiral centre in all amino acids, except gly (no chiral centre) thr and.
