MBIO 2420 Lecture Notes - Lecture 17: Biological Network, Cervical Cancer, Preferential Attachment

• School: University of Manitoba
• Department: Microbiology
• Course: MBIO 2420
• Professor: Dr.Peter Pelka

Document Summary

If a motif is found in virus its probably in cells: can find the function. Peripheral nodes - on the outside - only a few connect to it. Central nodes - in the inside - a lot connect to it a hub. Scale free: most proteins (nodes) have only a few interactions with other proteins. On the edges: very few proteins have many interactions. Key regulators of cell function: these are easily adaptable. Unless it"s a key node: new proteins prefer to connect to hubs (preferential attachment; rich get richer style growth) In general, the more essential the gene/protein/node is, the more highly connected it is. Random attack (natural disaster) - remove a random node, scale free network likely to survive as most nodes have few connections. Targeted attack (terrorist) - remove a key node - scale free network is very vulnerable as key node is highly connected/important.