MBIO 3010 Lecture Notes - Lecture 11: Cholera Toxin, Clostridium Perfringens Alpha Toxin, Ganglioside
17 Nov 2016
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Host doesn"t have to be infected by the bacterial cell, just protein -toxin. Can be passed on - cant do diagnosis on its own. Lyse many cells, not just in contact with blood. Causes cell to die but to stay attached to ecm, lump of dead cells you cant get rid of in your respiratory tract. Increases camp production - more slat secreted in lumen. Need binding site to be perfect and active site to be deactivated in order to make a vaccine. B-subunit binds to ganglioside receptors on nerve cells. B subunit binds to nerve cell receptor, a-subunit internalized arrangement. Continuous stimulation of motor neurons(aka muscles), spastic paralysis. Antibiotic has to be injected through skin, gt tract wont work. Gt tract is the easiest entry for drugs. Pathogen - nice way to spread to new host. Host - get rid of pathogen, loss of uid could be deadly. Allows host to get rid of infecting organisms.
