MBIO 3010 Lecture Notes - Lecture 32: Pseudopodia, Neutrophil, Abdominal Pain

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Heat sensitive - cooking food properly wont get rid of pathogen. Diarrhea with blood and pus (2-3 days) Endemic se asia, parts of sa and africa. Sensitive to stomach acid, large dose needed to cause disease unless patient is achlorhydric or taking antacids. Colonization of small intestine depends on motility (polar agella) production of mucinase and attachment to speci c receptors. Massive loss of uid and electrolytes (no damage to enterocytes; no blood or white blood cells in stool) Cholera toxin binds to cell membrane via b subunits. B subunit s change con rmation to allow a subunits to enter membrane. A subunits dissociate and a1 activates adenylate cyclase. Resistant to a variety of antibiotics - spore forming. Most common cause of hospital acquired diarrhea. Tcda (toxin a) and tcdb (toxin b) Produces mose tcda and b due to a deletion in regulatory gene (tcdc) Heat stable and resistant to stomach/small intestine enzymes.

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