MBIO 3010 Lecture Notes - Lecture 31: Pus, Guanylyl Cyclase, Immunodeficiency

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Organism must divide and multiply in host. Change balance of water and electrolytes in small bowel -> massive uid secretion. Penetrate intestinal mucosa -> spread and multiply outside of the bowel. Increase in uid and electrolyte loss in gut lumen. Allows host to get rid of pathogen. Usually mild and self-limiting, except very young, elderly and immunocompromised. Generally identity of the pathogen is not determined. Macroscopic and microscopic examination of feces for blood and pus. Six different groups with different pathogenic mechanisms. Binds to receptors on cell membrane of small intestine. Similar mode of action as cholera toxin. Increase in guanylate cyclase activity -> increase in cgmp levels -> increase in uid secretion. Acquired by uncooked meat, unpasteurized milk and contaminated water. Verotoxin receptors found on renal epithelium - may account for kidney damage. Anemia (fatigue, weakness, light-headedness) due to destruction of rbc. Low platelet count and sudden kidney damage.

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