MBIO 3430 Lecture Notes - Lecture 12: Tissue Plasminogen Activator, Exon Shuffling, Intron
24 Oct 2018
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Phase 0: aug gct gac (intron) gac. Phase 1: aug gct g(intron)ac gac. Phase 2: aug gct ga(intron)c gac. If introns old should not interrupt the original exons (genes) If introns recent they were added so addition of introns probably random = random phasing. If in a gene all introns are in the same phase: viewed as ancient introns (non random) Intron sliding could have caused this arrangement one insertion cause all introns to slide down one phase) but this would still show evidence they are ancient. Some introns found in the same location within the same gene: homologs/orthologs in plants, animals, fungi, ect. Some introns are phase 0, but many are not: some were found where the introns were all in phase one intron phase correlation, shows that even though i(cid:374)sertio(cid:374) is(cid:374)"t perfe(cid:272)t, its (cid:374)ot ra(cid:374)do(cid:373) Involved in breaking up blood cots: usually injected in people after a stroke, large family of genes.
