MBIO 4020 Lecture Notes - Lecture 10: Cytotoxic T Cell, Antigen-Presenting Cell, Interleukin 2

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T-reg cells (regulatory cells: controlling autoimmunity and turning down a specific ir when no longer needed. Il-4 and il-5 cause b cells to switch from igg or igm production to ige production also activate mast cells (with ige on them that release histamine) Major transcription factor gata3: turns on transcription of il-4 and il-13. Involved in fighting extracellular infections (tissues: bacteria or fungi living in ecf. If it does(cid:374)"t have a(cid:374) il-4 it cannot become a th2 cells: eve(cid:374)tually th2 cells (cid:373)ight lose the other receptors if it does(cid:374)"t (cid:374)eed the(cid:373) What determines the type of th cells generated: cytokines. What determined the cytokines: pmps binding to tlrs, cpg dna - humans -dna is usually methylated to control gene expression, but in bacteria there is less methylation. Il-4 is also released when mast cell binds pathogen or allergen via ige, emphasizes. Th2 response -> make more ige: ex.

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