MBIO 4020 Lecture Notes - Lecture 12: Red Pulp, White Pulp, Bone Marrow
13 Mar 2018
School
Department
Course
Professor
Document Summary
Primary organs: bone marrow - hematopoiesis, b cells mature - mig on surface, t cells partially mature - need to travel to the thymus to complete maturation. Tertiary tissues: also sites of lymphocyte -ag interactions. Tonsils: 3 sets, 2 sets at the back of the throat , at the sides, adenoids - in nasopharynx, network of reticular cells (structure) and follicles, mast cells and basophils ( associated with throat closing when allergies) covering -> skin and mucosal membranes: mucosal membranes -> respiratory tract, digestive, urogenital tract, more than 400 m2 of mucosal membranes. Galt lining of gut - tightly packed cells to block entry of pathogens: 3 locations for lymphocytes. Iga secreted across the epithelial layer into the lumen: some pathogens are able to exploit this, vibrio and poliovirus attack the m cells and gain entry through resulting gaps. Each chain of an ab contains several domains (independently folded regions) These domains are called immunoglobulin folds (ig folds)
