MBIO 4612 Lecture 12: Eukaryotes Lecture 12

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Mediator integrates & transduces +/- regulatory information from enhancers & promoter proximal elements recognized by tf to promoters. Functions directly through rna pol ii modulates its activity in promoter-dependent transcription. Identified the srb components (suppressors of rna polymerase b: together identified a variety of proteins now called the mediator. More experiments: mediator in yeast studied via srb4 mutant 5000+ genes showed dependence on. Srb4: mediator is essential for transcription (as important as pol, mediator functions in all pol ii promoters in yeast (and probably euks) Mammalian mediators probably variants of each other: thyroid receptor-associated proteins (trap) Isolated as a coactivator for thyroid receptor: vitamin d receptor-interacting proteins (drip) Isolated as a coactivator for vit. d receptor: similar composition to trap, activator-recruited cofactor (arc) Isolated as a coactivator for srebp-1a and sp1, also coactivator for. Isolated as an e1a-interacting multicomplex - binds activator domains in.

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