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Lecture 24

MBIO 1010 Lecture 24: Lecture 24

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University of Manitoba
MBIO 1010
Christopher Rathgeber

Microbiology 1010 – Lecture Notes Adaptive Response Properties (Continued…) Tolerance – inability to mount an adaptive immune response against self-antigens  Immune system cells that recognize self-antigens are destroyed during development. Primary and Secondary Immune Responses Primary response - The first time a new pathogen is encountered, the adaptive immune  response is weak The major result is the production of immunologic memory  Secondary response - The next time that pathogen is encountered memory cells are ready to respond  o Response can be so quick that the pathogen is unable to cause disease o ie. Immunity. Vaccines. End of secondary response, you produce memory (always put them back on the shelf). 128 Microbiology 1010 – Lecture Notes Immunogens and Antigens Immunogen – any foreign particle that can induce an adaptive immune response o Normally large molecules – proteins, polysaccharides, some lipids  Antigen – any substance that can react with antibodies or receptors on adaptive immune system cells. Immunogens and Antigens (Continued…) Antibody – Protein made by the immune system that can bind to, and inactivate foreign  antigens Epitope (or antigenic determinant) – The actual part of the antigen that can bind to an antibody o The more epitopes on an antigen, the more immunogenic it will be  o And the more diverse population of antibodies can be generated against it. Immunogens and Antigens (Continued…) Hapten – Low molecular weight compound too small to be immunogenic on its own, but can  be highly antigenic Example: Penicillin is small and non-immunogenic on its own o Can bind to proteins in the blood forming a strong immunogen o Antibodies are formed against it – leading to an allergic response. 129 Microbiology 1010 – Lecture Notes Cells of the Adaptive Immune System B lymphocytes (B cells)  Antibody producing cells Involved in the humoral immune response T lymphocytes (T cells) T-Cytotoxic cells (Tc cells) Destroy abnormal body cells (ex. cells infected by viruses) Involved in cell mediated r
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