Class Notes (809,452)
Canada (493,718)
Microbiology (494)
MBIO 1010 (75)
Lecture 21

MBIO 1010 Lecture 21: Lecture 21

4 Pages
Unlock Document

University of Manitoba
MBIO 1010
Christopher Rathgeber

Microbiology 1010 – Lecture Notes Leukocytes (white blood cells)  Cells that circulate in the blood and lymph, and reside in lymphoid organs Involved in both branches of the immune response (innate and adaptive)   Granulocytes o Cytoplasm contains granules filled with reactive chemicals  Can kill microbes Signal other components of immunity o 3 Types. Prefix “A” = means without Have granulates what have They create proteins that get sent to get tell the parts of the body to come to the certain area of the body (signal) for help. BEN = acronym for granulocytes 24.1 Leukocytes: Granulocytes Basophils and mast cells – granules stain with basic dyes Non-phagocytic  Circulate in blood (basophils) or reside in  mucosal tissue (mast cells) Can be triggered to degranulate  Release vasoactive mediators o Trigger inflammation o Ex. Histamine – involved in the allergic response. Inside the granules contain histamine= vasodilation and is a respirator inhibitor They limit inflammation in the body – histamine is helpful in normal blood vessel properties and digestion Eosinophils – granules stain with acidic dyes Non-phagocytic   Can leave the blood and enter tissues in areas of inflammation Attack large parasites: Protozoa and parasitic worms  Release reactive oxygen intermediates: O 2-, 2O 2, OH• o Destroy parasite from the outside. Spit digestive enzymes on the organism and you break it down extracellular and then the extra pieces is used for our own body. 115 Microbiology 1010 – Lecture Notes Neutrophils – granules are filled with digestive enzymes: o Lysozyme Defensins  Circulate in blood and migrate to infection sites Highly phagocytic – “eat” invading bacteria  Central component of innate immunity. 60% of WBC are neutrophils When the tissue is infectioned.. Vasodilation happens to the vessels get better and the cells spread out so there is more space for the neurtrophils leave the blood stream along with fluid to the site of the infection. This is why when we get a cut or infection.. There is edema / swelling happening. Leukocytes: Monocytes Monocytes – circulate in the blood, and then migrate into tissues and differentiate  into macrophages and dendritic cells Strongly phagocytic cells involved in antigen presentation   1. Macrophages Reside in tissues – lungs, liver, spleen, connective tissues  Specific surface molecules recognize pathogens – Toll-like receptors: o LPS, peptidoglycan, fungal cell walls etc. Induces phagocytosis. Dendritic cells – Reside in tissues that serve as common entry points for pathogens  Skin – “Langerhan’s cells”  Mucous membranes
More Less

Related notes for MBIO 1010

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.