MBIO 4020 Lecture Notes - Lecture 18: Apoptosis, Homologous Chromosome, Rheumatoid Arthritis
22 Mar 2018
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Document Summary
Common theme: ag that are normally tolerate (ignored) are attacked by is, causing damage to the host, autoimmunity - immune reponses against self ag (ex. Pancreas, myelin, ab receptors: allergy/hypersensitivity - immune response against non-harmful ag (ex. Autoimmunity: 1 in every 6 americans has an autoimmune disease, 2/3 woman, 1/3 men (out of those 1/6) Autoimmunity + allergy: regular immune response, result is harmful, rather than helpful, all require, a specific ag for activation (peanut, shrimp, ag processing and presentation, b + t activation, memory. Immediate type: driven by ige (allergy only - not autoimmune, hay fever, asthma, anaphylactic shock. Type ii: ab against cells or tissues. Type iii: ab against soluble components, generate immune complexes that cause problems. Type iv: cell mediated disease, ctls, phagocytes, delayed reactions (poison ivy) Type i: effectors being released from mast + basophils when fcer + ige bind to the ag, causes symptoms. Il-2 and il-4: signalling involves sequences called itams.
